Granulomatous inflammation involves the infiltration of inflammatory cells and tissue repair processes in a site of injury or infection. This inflammatory respo...
Granulomatous inflammation involves the infiltration of inflammatory cells and tissue repair processes in a site of injury or infection. This inflammatory response aims to eliminate pathogens or infected cells and promote tissue healing, but it can sometimes result in damage to surrounding tissues.
Examples:
Rheumatoid arthritis: In rheumatoid arthritis, chronic inflammation in the joints leads to damage of cartilage and bone, resulting in joint pain, stiffness, and disability.
Scleroderma: This autoimmune disease involves the excessive formation of blood vessels in the skin, leading to hardening and stiffness.
Tuberculosis: Granulomatous inflammation is a significant feature of tuberculosis, where infected macrophages and lymphocytes infiltrate and destroy tissue.
Granulomatous inflammation is characterized by the presence of inflammatory cells, such as macrophages, lymphocytes, and mast cells, along with the production of inflammatory mediators such as cytokines and chemokines. These inflammatory cells can infiltrate both healthy and infected tissue and damage surrounding cells, leading to tissue damage and dysfunction